Semaglutide, generally identified underneath the model names Ozempic and Wegovy, has taken the load loss world by storm. And, because it helps with weight reduction, it’s good for sort 2 diabetes, as weight reduction is the first method to reverse the signs of sort 2 diabetes. Semaglutide does scale back urge for food since you really feel fuller longer. Nevertheless, it isn’t a miracle remedy, and it comes with unwanted effects. I’ve written beforehand about Ozempic face, weight reduction plateaus, regaining weight after you cease Ozempic, ineffectiveness for some folks, in addition to pure options and fiber-rich meals that naturally work like semaglutide, simply to a lesser diploma. However now a brand new aspect impact is rising—SIBO (small intestinal bacterial overgrowth). So, let’s take a better have a look at this.
Understanding SIBO and Its Connection to Semaglutide
SIBO happens when extreme micro organism develop within the small gut, resulting in signs like bloating, diarrhea, stomach ache, and meals intolerances. An absence of intestine motility could also be a part of the reason for SIBO, together with a low manufacturing of hydrochloric acid within the abdomen. In the long run, the pure defenses of the small gut are compromised, and SIBO outcomes.
The Printed Case Report of SIBO and Semaglutide
A case report revealed in Canadian Journal of Physiology and Pharmacology describes a 35-year-old male who managed to lose 50 kilos ( 22.7 kg) over 120 days on oral semaglutide. Although he had earlier lactose intolerance, it bought worse whereas taking semaglutide. And he additionally developed a brand new gluten intolerance. Then about six months after discontinuing semaglutide, he was recognized with SIBO, suggesting the drug might have contributed to or made this situation worse. The truth that the meals intolerances didn’t simply go away when he stopped taking semaglutide is very regarding. Apparently, there was a change each within the GI tract motility and the micro organism that loved these situations that endured after the drug was stopped.
How Semaglutide May Contribute to SIBO
Semaglutide’s essential impact is slowing down the emptying of the abdomen and slowing down intestinal transit. That impact makes you’re feeling full longer for sue, nevertheless it additionally creates the right atmosphere for micro organism to proliferate within the small gut. Micro organism die-off within the abdomen isn’t excellent, and the micro organism load may be substantial. So, even when 1 in 10,000 micro organism get by way of, however they get to hang around within the small gut and adapt resistance to bile salts, then they will colonize the small gut and dwell off the sugars and brief chain carbohydrates that come their method.
This case report is simply from one man, however anecdotal experiences from different clinicians recommend that is removed from the one case. If you have already got sort 2 diabetes, and have any form of meals intolerances, this new aspect impact ought to provide you with pause. Do you actually need to take care of SIBO?
Semaglutide’s Aspect Impact Record is Getting Longer
In our earlier articles about weight reduction and semaglutide, we’ve lined a number of unwanted effects related to semaglutide. “Ozempic Face: Find out how to Lose Weight With out Wanting Older” mentioned the gaunt, aged look some customers expertise attributable to fast fats and muscle loss when taking semaglutide. “Find out how to Overcome a Weight Loss Plateau” explored why progress stalls for some. Within the article “Battling Ozempic Not Working? Right here’s Find out how to Repair It” I talked about how Ozempic doesn’t work for everyone, and the widespread myths that individuals imagine about weight reduction medication. I didn’t speak in regards to the uncommon unwanted effects like elevated threat of pancreatitis.
SIBO provides an entire new form of aspect impact to the record. Not like beauty issues about Ozempic face, or plateauing weight reduction, SIBO actually impacts your high quality of life. It’s most likely worse than the diabetes itself. You will need to a minimum of briefly use a low FODMAP food regimen to handle the bloating and diarrhea. It’s a very restrictive food regimen and doesn’t actually assist you get higher both.
For some folks, the trade-off of straightforward weight reduction with Ozempic for a persistent case of SIBO. I do know just a few individuals who have struggled with SIBO for years and nonetheless haven’t overcome it. I believe coping with sort 2 diabetes is way simpler than overcoming SIBO. Attempting to vary entrenched micro organism within the intestinal tract is a troublesome proposition.
We’ve a number of articles about concepts for sustainable weight reduction. You’ll be able to see an outline of them within the article, “The Full Information to Wholesome Weight Loss: What Works and Why.” In any case, even with weigh loss medication, to achieve success long-term you need to be taught to eat wholesome meals, and get train to keep up weight reduction.
Conclusion: Is Semaglutide Well worth the Dangers?
Semaglutide is a robust drug for serving to folks drop some pounds. Nevertheless it has drawbacks. If you find yourself with SIBO, you may need wished that you simply had by no means taken the drug to begin with. It isn’t identified but how prevalent the incidence of SIBO is with semaglutide use. But when you have already got meals intolerances, you most likely have the next probability of SIBO with the drug.
As talked about above, it’s best to take a look at our information on sustainable weight reduction ideas. There are options to happening a crash course with Ozempic.